Enfield was originally inhabited by the Pocomtuc tribe, and contained their two villages of Scitico and Nameroke. Enfield was settled in 1679 by settlers from Salem, Massachusetts. Enfield was incorporated in Massachusetts in 1683. In 1749, following the settlement of a lawsuit in which it was determined that a surveyors error placed a section of present-day Hartford County (including Enfield) within the boundaries of Massachusetts, the town seceded and became part of Connecticut.
Jonathan Edwards preached his famous sermon, "Sinners in the Hands of an Angry God" in Enfield. This sermon is one of the most famous sermons ever scripted. This was part of the Great Awakening Revival that struck New England in the mid-1700s and spread throughout Western Civilization.